Nkhani

Mankhwala azitsamba akhala amtengo wapatali kwa zaka zambiri chifukwa chopereka chidziwitso cha matenda osiyanasiyana.Komabe, kupatula mamolekyu enaake ogwira ntchito ku mitundu ya zomera zambiri kungakhale ntchito yovuta.Tsopano, ofufuza a ku yunivesite ya Toyama, ku Japan apanga njira yodzipatula ndikuzindikira mankhwala omwe amagwira ntchito muzomera.

Zatsopano - zosindikizidwa posachedwa mu Frontiers in Pharmacology m'nkhani yamutu wakuti, "Njira Yadongosolo Yopezera Mankhwala Ochizira a Matenda a Alzheimer's ndi Molecule Yake Yachindunji.", wonetsani kuti njira yatsopano imazindikiritsa zinthu zingapo zomwe zimagwira ntchito kuchokera ku Drynaria rhizome, mankhwala azitsamba azitsamba, omwe amawongolera kukumbukira ndikuchepetsa mawonekedwe a matenda amtundu wa mbewa wa matenda a Alzheimer's.

Nthawi zambiri, asayansi amawunika mobwerezabwereza mankhwala opangira ma labu kuti awone ngati pali mankhwala omwe amakhudza ma cell omwe amamera mu vitro.Ngati mankhwala akuwonetsa zotsatira zabwino m'maselo kapena machubu oyesera, amatha kugwiritsidwa ntchito ngati mankhwala, ndipo asayansi amapitiliza kuyesa nyama.Komabe, zimenezi n’zotopetsa ndipo sizitengera kusintha kwa mankhwala akamalowa m’thupi—ma enzymes a m’magazi ndi m’chiwindi amatha kugaŵa mankhwala m’njira zosiyanasiyana zotchedwa metabolites.Kuonjezera apo, mbali zina za thupi, monga ubongo, zimakhala zovuta kupeza mankhwala ambiri, ndipo mankhwala ena okha kapena ma metabolites awo adzalowa m'matumbowa.

"Mipangidwe yomwe imadziwika m'mawonekedwe amankhwala azitsamba amtundu wamankhwala sizomwe zimachitika nthawi zonse chifukwa zoyesererazi zimanyalanyaza biometabolism ndi kugawa kwa minofu," adatero wofufuza wamkulu Chihiro Tohda, Ph.D., pulofesa wothandizira wa neuropharmacology ku yunivesite ya Toyama. ."Chifukwa chake, tinali ndi cholinga chopanga njira zabwino zodziwira zinthu zenizeni zomwe zimagwira ntchito zomwe zimaganizira izi."

Mu phunziroli, gulu la Toyama linagwiritsa ntchito mbewa zokhala ndi kusintha kwa majini monga chitsanzo cha matenda a Alzheimer's.Kusintha kumeneku kumapatsa mbewa makhalidwe ena a matenda a Alzheimer's, kuphatikizapo kuchepa kwa kukumbukira ndi kuchuluka kwa mapuloteni mu ubongo, otchedwa amyloid ndi tau mapuloteni.

"Timapereka lipoti la njira yowunikira anthu omwe ali ndi mankhwala achilengedwe omwe amagwiritsidwa ntchito pa matenda a Alzheimer's (AD)," olembawo adalemba."Tidapeza kuti Drynaria rhizome imatha kupititsa patsogolo kukumbukira ndikuwongolera ma pathologies a AD mu mbewa za 5XFAD.Kusanthula kwa biochemical kunapangitsa kuti azindikire ma metabolites a bioeffective omwe amasamutsidwa ku ubongo, omwe ndi naringenin ndi ma glucuronides ake.Kuti tifufuze momwe zimagwirira ntchito, tidaphatikiza kukhazikika kwa chandamale chokhudzana ndi mankhwala ndi immunoprecipitation-liquid chromatography/mass spectrometry kusanthula, kuzindikira mapuloteni a collapsin reaction mediator protein 2 (CRMP2) ngati chandamale cha naringenin. ”

Asayansi adapeza kuti chomeracho chimachepetsa kuwonongeka kwa kukumbukira komanso kuchuluka kwa mapuloteni a amyloid ndi tau muubongo wa mbewa.Kuphatikiza apo, gululo lidayang'ana minofu yaubongo wa mbewa patadutsa maola asanu atachiritsa mbewazo.Iwo anapeza kuti zinthu zitatu za m’mbewuzo zinapanga ubongo kukhala naringenin ndi ma metabolites awiri a naringenin.

Ofufuzawo atagwira mbewazo ndi naringenin yoyera, adawonanso kusintha komweku pakusokonekera kwa kukumbukira komanso kuchepa kwa mapuloteni a amyloid ndi tau, kutanthauza kuti naringenin ndi metabolites ake ndizomwe zimagwira ntchito muzomera.Anapeza puloteni yotchedwa CRMP2 yomwe naringenin imamangiriza ku ma neuroni, zomwe zimawapangitsa kuti akule, kutanthauza kuti iyi ikhoza kukhala njira yomwe naringenin imatha kusintha zizindikiro za matenda a Alzheimer's.

Ofufuzawa ali ndi chiyembekezo chakuti njira yatsopanoyi ingagwiritsidwe ntchito kuzindikira mankhwala ena."Tikugwiritsa ntchito njirayi kuti tipeze mankhwala atsopano a matenda ena monga kuvulala kwa msana, kuvutika maganizo, ndi sarcopenia," adatero Dr. Tohda.